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Liška, A.; Chrenko, D.; Zatloukalová, M.; Klíma, J.; Papoušková, B.; Kabeláč, M.; Ludvík, J.; Pospíšil, J.; Vacek, J.
Redox Behaviour of Nitro-Fatty Acids and Their Ester
Electrochimica Acta 2026, 545 (n/a), 147698 (p. 1-12). DOI: 10.1016/j.electacta.2025.147698

Krajcovicova, S.; Wharton, T.; Driscoll, C. L.; King, T. A.; Howarth, M. R.; Spring, D. R.
A Platform for SpyCatcher Conjugation to Native Antibodies
Chemical Science 2025, 2025 (16), 10602-10609. DOI: https://doi.org/10.1039/D5SC02286J

Chrenko, D.; Pereckova, J.; Zatloukalová, M.; Vacek, J.; Pospíšil*, J.; Perecko*, T.
Regio- and Stereoselective Synthesis of Nitro-fatty Acids as NRF2Pathway Activators Working under Ambient or Hypoxic Conditions
Journal of Medicinal Chemistry 2025, 68 (11), 12172-12184. DOI: 10.1021/acs.jmedchem.5c00982

Kazakova, A.; Frydrych, I.; Jakubcová, N.; Pokorný, J.; Lišková, B.; Gurská, S.; Buriánová, R.; Přibylka, A.; Džubák, P.; Hajdúch, M.; Urban, M.
Triterpenoid phthalimides as selective anti-cancer agents targeting mitochondrial apoptosis
Eur. J. Med. Chem. 2025, 283 (-), 117126 (1-23). DOI: 10.1016/j.ejmech.2024.117126

Chasák, J.; Janicki, I.; Brulíková, L.*
The Liebeskind–Srogl cross-coupling reaction towards the synthesis of biologically active compounds
Eur. J. Med. Chem. 2025, 290 (-), 117526. DOI: 10.1016/j.ejmech.2025.117526

Salaga, M.; Binienda, A.; Canale, V. ; Grychowska, K.; Soural, M.; Marin, P.; Zajdel , P.
Serotonin type 6 receptor inverse agonists and neutral antagonists inhibit defecation: relevance to intestinal motility disorders
Eur. J. Pharmacol. 2025, 1005 (-), 178099-178105. DOI: 10.1016/j.ejphar.2025.178099

Zůvalová, I.; Grycová, A.; Hrubý, J.; Illes, P.; Soural, M.; Kováč, O.; Šebela, M.; Bachleda, P.; Kriegová, E.; Trajerová, M.; Dvořák, Z.
Methylcarvones as immunomodulators through antagonism of aryl hydrocarbon receptor
Bioorg. Chem. 2025, 167 (-), 109256-109265. DOI: doi.org/10.1016/j.bioorg.2025.109256

Zůvalová, I.; Vyhlídalová, B.; Ondrová, K..; Nádvorník, P.; Hrubý, J.; Illés, P.; Soural, M.; Šebela, M.; Šindlerová, L.; Kubala, L.; Mani, S.; Dvořák, Z.
Decoding structural determinants of aryl hydrocarbon receptor antagonism by monoterpenoids
Bioorg. Chem. 2025, – (-), 108265. DOI: doi.org/10.1016/j.bioorg.2025.108265

Kazakova, A.; Frydrych, I.; Jakubcová, N; Pokorný. J.; Lišková, B.; Gurská, S.; Džubák, P.; Hajdúch, M.; Urban, M.
Novel triterpenoid pyrones, phthalimides and phthalates are selectively cytotoxic in CCRF-CEM cancer cells – Synthesis, potency, and mitochondrial mechanism of action
Eur. J. Med. Chem. 2024, 269 (N/A), 116336 (1-16). DOI: 10.1016/j.ejmech.2024.116336

Petřík, I.; Pěnčík, A.; Stýskala, J.; Tranová, L.; Amakorová; P.; Strnad, M.; Novák, O.
Rapid profiling of cytokinins using supercritical fluid chromatography coupled with tandem mass spectrometry
Analytica Chimica Acta 2024, 1258 (n/a), 342010(1-10). DOI: 10.1016/j.aca.2023.342010

Rode, A.; Müller, N.; Kováč, O.; Wurst, K.; Magauer, T.
A General Entry to Ganoderma Meroterpenoids: Synthesis of Applanatumol E, H, and I, Lingzhilactone B, Meroapplanin B, and Lingzhiol
Org. Lett. 2024, 26 (42), 9017-9021. DOI: https://doi.org/10.1021/acs.orglett.4c03192

Müller, N.; Kováč, O.; Rode, A.; Atzl, D.; Magauer, T.*
Total Synthesis of Ganoapplanin Enabled by a Radical Addition/Aldol Reaction Cascade
J. Am. Chem. Soc. 2024, 146 (33), 22937-22942. DOI: https://doi.org/10.1021/jacs.4c08291

Bon, D.J.-Y. D.; Chrenko, D.; Kováč, O.; Ferugová, V.; Lasák, P.; Fuksová, M.; Zálešák, F.; Pospíšil, J.;
Julia-Kocienski-like connective C-C and C=C bond-forming reaction
Adv. Synth. Cat. 2024, 366 (3), 480-487. DOI: 10.1002/adsc.202301054

Pospíšilová, J.; Toman, D.; Ručil, T.; Cankař, P.
D-Hexopyranosides with Vicinal Nitrogen-Containing Functionalities
Molecules 2024, 29 (15), 3465/1-3465/28. DOI: 10.3390/molecules29153465

Chrenko, D.; Pospíšil, J.
Latest Developments of the Julia–Kocienski Olefination Reaction: Mechanistic Considerations
Molecules 2024, 29 (12), 2719 (19 pages). DOI: 10.3390/molecules29122719

Žáková, K.; Králová, P.; Soural, M.
Synthesis of 2-amino-3-arylindoles and their fused analogues via intramolecular C-arylation
Adv. Synth. Catal. 2024, 366 (11), 2519-2526. DOI: 10.1002/adsc.202400143

Králová, P.; Soural, M.
Biological properties of pyrroloquinoline and pyrroloisoquinoline derivatives
Eur. J. Med. Chem 2024, 269 (-), 116287 (1-42). DOI: doi.org/10.1016/j.ejmech.2024.116287

Sydenham J. D. ; Seki, H.; Krajcovicova, S.; Schober, T.; Zeng, L.; Deingruber, T. ; Spring D. R.
Site-Selective Peptide Functionalisation Mediated via Vinyl-Triazine Linchpins
Chem. Commun. 2024, 60 (-), 706-709. DOI: 10.1039/D3CC05213C

Aseel Kashkush, Judith Furth-Lavi, Jiri Hodon, Raphael I. Benhamou
PROTAC and Molecular Glue Degraders of the Oncogenic RNA Binding Protein Lin28
Macromolecular bioscience 2024, 24 (-), -. DOI: https://doi.org/10.1002/mabi.202400427

Strnad, J.; Soural, M.; Šebela, M.
A New Activity Assay Method for Diamine Oxidase Based on Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry
Molecules 2024, 29 (-), 4878-4892. DOI: 10.3390/molecules29204878

Cankařová, N.*; Krchňák, V.
Regioselective Cyclic Iminium Formation of Ugi Advanced Intermediates: Rapid Access to 3,4-Dihydropyrazin-2(1H)-ones and Other Diverse Nitrogen-Containing Heterocycles
Molecules 2023, 28 (7), 3062 (1-17). DOI: 10.3390/molecules28073062

Tkadlecová, M.; Lemrová, B.; Soural, M.
Synthesis of Polysubstituted Pyridines and Pyrazines via Truce-Smiles Rearrangement of Amino Acid-based 4-Nitrobenzenesulfonamides
J. Org. Chem. 2023, 88 (5), 3228-3237. DOI: 10.1021/acs.joc.2c03025

Tomanová, M.; Vaňková, I.; Toman, D.; Přibylka, A.; Nemec, I.; Cankař, P.
Axially Chiral Sulfonic Acids for Brønsted Acid Catalysis: 8-Benzoimidazolylnaphthalene-1-sulfonic Acids and Their Derivatives
J. Org. Chem. 2023, 88 (13), 9265–9276. DOI: 10.1021/acs.joc.3c00818

Ondrová, K.; Zůvalová, I.; Vyhlídalová, B.; Krasulová, K.; Miková, E.; Vrzal, R.; Nádvorník, P.; Nepal, B.; Kortagere, S.; Kopečná, M.; Kopečný, D.; Šebela, M.; Rastinejad, F.; Pu, H.; Soural, M.; Rolfes, K. M.; Haarmann-Stemmann, T.; Li, H.; Mani, S.; Dvořák, Z.
Monoterpenoid aryl hydrocarbon receptor allosteric antagonists protect against ultraviolet skin damage in female mice
Nat. Commun. 2023, 14 (-), 2728-2743. DOI: 10.1038/s41467-023-38478-6

Krajcovicova, S.*; Spring, D. R.
Tryptophan in Multicomponent Petasis Reactions for Peptide Stapling and Late-Stage Functionalisation
Angew. Chem. Int. Ed. 2023, 62 (-), e202307782. DOI: 10.1002/anie.202307782

Iegre, J.‡; Krajcovicova, S.‡; Gunnarsson, A.; Wissler, L.; Kaeck, H.; Luchniak, A.; Tangefjord, S.; Narjes, F.; Spring, D. R.
A cell-active cyclic peptide targeting the Nrf2/Keap1 protein–protein interaction
Chem. Sci. 2023, 14 (-), 10800-10805. DOI: 10.1039/D3SC04083F

King, T.; Walsh, S.; Kapun, M.; Wharton, T.; Krajcovicova, S.; Glossop, M.; Spring, D. R.
Disulfide re-bridging reagents for single-payload antibody-drug conjugates
Chem. Commun. 2023, 59 (-), 9868-9871. DOI: 10.1039/D3CC02980H

Šamšulová, V.; Šedivá, M.; Kóňa, J. ; Klaudiny, J.; Poláková, M.
A Comparison of the Antibacterial Efficacy of Carbohydrate Lipid‐like (Thio)Ether, Sulfone, and Ester Derivatives against Paenibacillus larvae
Molecules 2023, 28 (-), 2516. DOI: doi.org/10.3390/molecules28062516

Supiková, K.; Kosinová, A.; Vavruša, M.; Kopliková, L.; Francois, A.; Pospíšil, J.; Zatloukal, M.; Wever, R.; Hartog, A.; Grúz, J.
Sulfated phenolic acids in plants
Planta 2022, 255 (na), 124 (1-12). DOI: 10.1007/s00425-022-03902-6

Borková, L.; Frydrych, I.; Vránová, B.; Jakubcová, N.; Lišková, B.; Gurská, S.; Džubák, P.; Pavliš, P.; Hajdúch, M.; Urban, M.
Lupane derivatives containing various aryl substituents in the position 3 have selective cytostatic effect in leukemic cancer cells including resistant phenotypes
Eur. J. Med. Chem. 2022, 244 (N/A), 114850. DOI: 10.1016/j.ejmech.2022.114850

Hodoň, J.; Frydrych, I.; Trhlíková, Z.; Pokorný, J.; Borková, L.; Benická, S.; Vlk, M.; Lišková, B.; Kubíčková, A.; Medvedíková, M.; Pisár, M.; Sarek, J.; Das, V.; Ligasová, A.; Koberna, K.; Džubák, P.; Hajdúch, M.; Urban, M.
Triterpenoid pyrazines and pyridines – synthesis, cytotoxicity, mechanism of action, preparation of prodrugs
Eur. J. Med. Chem. 2022, 243 (N/A), 114777. DOI: 10.1016/j.ejmech.2022.114777

Sobczak, K.; Rudnicki, K.; Jedinak, L.; Zatloukalova, M.; Vacek, J.; Poltorak, L.
Oleic and nitro-oleic acid behavior at an electrified water-1,2-dichloroethane interface
J. Mol. Liquids 2022, 2022 (365) (N/A), 120110(1-6). DOI: 10.1016/j.molliq.2022.120110

Králová, P.; Soural, M.
Synthesis of Polycyclic Tetrahydroisoquinolines and Tetrahydrobenzo[d]azepines from Polymer-Supported Allylglycine
J. Org. Chem. 2022, 87 (8), 5242–5256. DOI: 10.1021/acs.joc.2c00039

Zhang, H.X.; Daněk, O.; Makarov, D.; Rádl, S.; Kim, D.; Ledvinka, J.; Vychodilová, K.; Hlaváč, J.; Lefebre, J.; Denis, M.; Rademacher, C.; Ménová, P.
Drug-like Inhibitors of DC-SIGN Based on a Quinolone Scaffold
ACS Med. Chem. Letters 2022, 13 (6), 935-942. DOI: 10.1021/acsmedchemlett.2c00067

Hernychová, L.; Alexandri, E.; Tzakos, A. G.; Zatloukalová, M.; Primikyri, A.; Gerothanassis, I. P.; Uhrik, L.; Šebela, M.; Kopečný, D.; Jedinák, L.; Vacek, J.
Serum albumin as a primary non-covalent binding protein for nitro-oleic acid
Int. J. Biol. Macromol. 2022, 2022 (203) (4), 116-129. DOI: 10.1016/j.ijbiomac.2022.01.050

Matvieiev, O.; Šelešovská, R.; Vojs, M.; Marton, M.; Michniak, P.; Hrdlička, V.; Hatala, M.; Janíková, L.; Chýlková, J.; Skopalová, J.; Cankař, P.; Navrátil, T.
Novel Screen-Printed Sensor with Chemically Deposited Boron-Doped Diamond Electrode: Preparation,Characterization, and Application
Biosensors 2022, 12 (4), 241(1-21). DOI: 10.3390/bios12040241

Tomanová, M.; Kozlanská, K.; Jorda, R.; Jedinák, L.; Havlíková, T.; Řezníčková, E.; Peřina, M.; Klener, P.; Dolníková, A.; Cankař, P.; Kryštof, V.
Synthesis and Structural Optimization of 2,7,9-Trisubstituted purin-8-ones as FLT3-ITD Inhibitors
Int. J. Mol. Sci. 2022, 23 (24), 16169. DOI: 10.3390/ijms232416169

Okorochenkov, S.; Škrott, Z.; Majera, D.; Porubský, M.; Mistrik, M.; Hlaváč, J.
BODIPY-aza-indole derivate complex as a selective fluorescent sensor for autolysosomes detection
Sens. Actuator B-Chem. 2022, 351 (-), 130941. DOI: 10.1016/j.snb.2021.130941

Řezníčková, E.; Krajčovičová, S.; Peřina, M.; Kovalová, M.; Soural, M.; Kryštof, V.
Modulation of FLT3-ITD and CDK9 in acute myeloid leukaemia cells by novel proteolysis targeting chimera (PROTAC)
Eur. J. Med. Chem. 2022, 243 (-), 114792. DOI: 10.1016/j.ejmech.2022.114792

Dak, M.; Šlachtová, V.; Šebela, M.; Bazgier, V.; Berka, K.; Smiejkowska, N.; Oorts, L.; Cappoen, D.; Brulíková, L.*
Novel heterocyclic hydroxamates as inhibitors of the mycobacterial zinc metalloprotease Zmp1 to probe its mechanism of function
Eur. J. Med. Chem. 2022, 244 (-), 114831 (1-15). DOI: 10.1016/j.ejmech.2022.114831

Cankařová, N.*; Nemec, I.; Krchňák, V.
p-TSA-Mediated Four-Component Reaction: One-Step Access to Mesoionic 1H-Imidazol-3-ium-4-olates, Direct NHC Precursors
Adv. Synth. Catal. 2022, 364 (-), 2996-3003. DOI: 10.1002/adsc.202200398

Porubský, M.; Řezníčková, E.; Křupková, S.; Kryštof, V.; Hlaváč, J.
Development of fluorescent dual-FRET probe for simultaneous detection of caspase-8 and caspase-9 activities and their relative quantification
Bioorg. Chem. 2022, 129 (-), 106151. DOI: 10.1016/j.bioorg.2022.106151

Novosád, D.; Hrenakova, M.; Vacek, J.; Storch, J.; Stýskala, J.; Hrbáč, J.
Cyclopentenedione-based ascorbate-rejecting permselective layers prepared by electropolymerization
J. Electroanal. Chem. 2022, 912 (-), 116261(1-10). DOI: 10.1016/j.jelechem.2022.116261

Zatloukalová, M.; Jedinák, L.; Riman, D.; Franková, D.; Novák, D.; Cytryniak, A.; Nazaruk, E.; Bilewicz, R.; Vrba, J.; Papoušková, B.; Kabeláč, M.; Vacek, J.
Cubosomal lipid formulation of nitroalkene fatty acids: Preparation, stability and biological effects
Redox Biology 2021, 46 (n/a), 102097(1-14). DOI: 10.1016/j.redox.2021.102097

Pokorný, J.; Olejníková, D.; Frydrych, I.; Lišková, B.; Gurská, S.; Benická, S.; Šarek, J.; Kotulová, J.; Hajdúch, M.; Džubák, P.; Urban, M.
Substituted dienes prepared from betulinic acid – Synthesis, cytotoxicity, mechanism of action, and pharmacological parameters
Eur. J. Med. Chem. 2021, 224 (n/a), 113706(1-18). DOI: 10.1016/j.ejmech.2021.113706

Gonzalez, G.; Hodoň, J.; Kazakova, A.; D’Acunto, C. W.; Kaňovský, P.; Urban, M.; Strnad, M.
Novel pentacyclic triterpenes exhibiting strong neuroprotective activity in SH-SY5Y cells in salsolinol- and glutamate-induced neurodegeneration models
Eur. J. Med. Chem. 2021, 213 (n/a), 113168. DOI: 10.1016/j.ejmech.2021.113168

Porubsky, M. ; Gurska, S. ; Stankova, J.; Hajduch, M.; Dzubak, P.; Hlavac, J.
AminoBODIPY Conjugates for Targeted Drug Delivery Systems and Real-Time Monitoring of Drug Release
Molecular Pharmaceutics 2021, 18 (6), 2385–2396. DOI: 10.1021/acs.molpharmaceut.1c00219

Kriegelsteinová, P.; Lemrová, B.; Ručilová, V.; Soural, M.
Copper-free solid-phase synthesis of triazolo[1,5-a][1,4]diazepin-6-ones
Adv. Synth. Catal. 2021, 363 (4), 1112-1119. DOI: 10.1002/adsc.202001403

Vanda, D.; Canale, V.; Chaumont-Dubel, S.; Kurczab, R.; Satała, G.; Koczurkiewicz, P.; Krawczyk, M.; Pietruś, W.; Blicharz, K.; Pękala, E.; Bojarski, A.; Popik, P.; Marin, P.; Soural, M.; Zajdel, P.
Imidazopyridine-based 5-HT6 receptor neutral antagonists: impact of N1-benzyl and N1-phenylsulfonyl fragments on different receptor conformational state
J. Med. Chem. 2021, 64 (2), 1180-1196. DOI: 10.1021/acs.jmedchem.0c02009

Tranová, L.; Stýskala, J.
Study of the N7 Regioselective Glycosylation of 6-Chloropurine and 2,6-Dichloropurine with Tin and Titanium Tetrachloride
J. Org. Chem. 2021, 86 (19), 13265-13275. DOI: 10.1021/acs.joc.1c01186

Zálešák, F.; Kováč, O.; Lachetová, E.; Šťastná, N.; Pospíšil,J.
Unified approach to benzo[d]thiazol-2-yl-sulfonamides
J. Org. Chem. 2021, 86 (17), 11291-11309. DOI: 10.1021/acs.joc.1c00317

Krajčovičová, S.; Danišková, A.; Bendová, K.; Nový, Z.; Soural, M.; Petřík, M.
[68Ga]Ga-DFO-c(RGDyK): synthesis and evaluation of its potential for tumor imaging in mice
Int. J. Mol. Sci. 2021, 22 (14), 7391(1-16). DOI: 10.3390/ijms22147391

Králová, P.; Soural, M.
Reagent-Based Diversity-Oriented Synthesis of Triazolo[1,5-a][1,4]diazepine Derivatives from Polymer-Supported Homoazidoalanine
J. Org. Chem. 2021, 86 (12), 7963-7974. DOI: 10.1021/acs.joc.1c00293

Iakovenko, R.; Hlaváč, J.
Visible light-mediated metal-free double bond deuteration of substituted phenylalkenes
Green. Chem. 2021, 23 (1), 440-446. DOI: 10.1039/D0GC03081C

Ručilová, V.; Świerczek, A.; Vanda, D.; Funk, P. ; Lemrová, B.; Gawalska, A.; Bucki, A.; Nowak, B.; Zadrożna, M.; Pociecha, K.; Soural, M.; Wyska, E.; Pawłowski, M.; Chłoń-Rzepa, G.; Zajdel, P.
New Imidazopyridines with Phosphodiesterase 4 and 7 Inhibitory Activity and Their Efficacy in Animal Models of Inflammatory and Autoimmune Diseases
Eur. J. Med. Chem. 2021, 209 (-), 112854(1-18). DOI: 10.1016/j.ejmech.2020.112854

Chasák, J.; Šlachtová, V.; Urban, M.; Brulíková, L.*
Squaric acid analogues in medicinal chemistry
Eur. J. Med. Chem. 2021, 209 (-), 112872 (1-23). DOI: 10.1016/j.ejmech.2020.112872

Krajčovičová, S.; Jorda, R.; Vanda, D..; Soural, M.; Kryštof, V.
1,4,6-Trisubstituted imidazo[4,5-c]pyridines as inhibitors of Bruton’s tyrosine kinase
Eur. J. Med. Chem. 2021, 211 (-), 113094 (1-10). DOI: 10.1016/j.ejmech.2020.113094

Urban, M.; Šlachtová, V.; Brulíková, L.*
Small organic molecules targeting the energy metabolism of Mycobacterium tuberculosis
Eur. J. Med. Chem. 2021, 212 (-), 113139 (1-17). DOI: 10.1016/j.ejmech.2020.113139

Tan, S.; Abas, M.; Verstraeten, I.; Glanc, M.; Molnár, G.; Hajný, J.; Lasák, P.; Petřík, I.; Russinova, E.; Petrášek, J.; Novák, O.; Pospíšil, J.; Friml, J.*
Salicylic Acid Targets Protein Phosphatase 2A to Attenuate Growth in Plants
Curr. Biol. 2020, 30 (n/a), 381-395. DOI: 10.1016/j.cub.2019.11.058

Borková, L.; Frydrych, I.; Jakubcová, N.; Adámek, R.; Lišková, B.; Gurská, S.; Medvedíková, M.; Hajdúch, M.; Urban, M.
Synthesis and biological evaluation of triterpenoid thiazoles derived from betulonic acid, dihydrobetulonic acid, and ursonic acid
Eur. J. Med. Chem. 2020, 185 (N/A), Article Number: UNSP 111806 (1-18). DOI: 10.1016/j.ejmech.2019.111806

Kováč, O.; Zálešák, F.; Bon, D.J.-Y.D; Roiser, L.; Baar, L.V.; Waser, M.; Pospíšil, J.
risubstituted highly activated benzo[d]thiazol-2-yl-sulfone-containing olefins as building blocks in organic synthesis
J. Org. Chem. 2020, 85 (n/a), 7192-7206. DOI: 10.1021/acs.joc.0c00571

Mathieu, A.S.; Dobrev, P.I.; Tarkowská, D.; Pospíšil, J.; Motyka, V.; Jacquemin, G.; Quinet, M.; Lutts, S.
Phytohormone profile and CiFL1 expression in young seedlings of Cichorium intybus L. var sativum exposed to high temperature in relation to vernalization and de-vernalization processes
Environ. Exp. Bot. 2020, 178 (n/a), 104127 (1-13). DOI: 10.1016/j.envexpbot.2020.104127

Filová, E.; Tonar, Z.; Lukášová, V.; Buzgo, M.; Litvinec, A.; Rampichová, M.; Beznoska, J.; Plencner, M.; Staffa, A.; Daňková, J.; Soural, M.; Chvojka, J.; Malečková, A.; Králíčková, M.; Amler, E.
Hydrogel containing anti-CD44-labeled microparticles, guide bone tissue formation in osteochondral defects in rabbits
Nanomaterials 2020, 10 (8), 1504-1521. DOI: 10.3390/nano10081504

Cankařová, N.*; Krchňák, V.
Isocyanide Multicomponent Reactions on Solid Phase: State of the Art and Future Application
Int. J. Mol. Sci. 2020, 21 (23), 9160 (1-48). DOI: 10.3390/ijms21239160

Kriegelstein, M.; Profous, D.; Přibylka, A.; Cankař, P.
The Assignment of the Absolute Configuration of β-Chiral Primary Alcohols with Axially Chiral Trifluoromethylbenzimidazolylbenzoic Acid
J. Org. Chem. 2020, 85 (20), 12912–12921. DOI: 10.1021/acs.joc.0c01510

Králová, P.; Maloň, M.; Pospíšil, J.; Soural, M.
Rearrangement of Threonine and Serine-Based N-(3-Phenylprop-2-yn-1-yl) Sulfonamides Yields Chiral Pyrrolidin-3-ones
J. Org. Chem. 2020, 85 (2), 985-993. DOI: 10.1021/acs.joc.9b02932

Schütznerová, E.; Přibylka, A.; Medran, N. S.; Krchňák, V.
Greening Solid-Phase Organic Synthesis: Environmentally Conscious Synthesis of Pharmaceutically Relevant Privileged Structures 5,6-Dihydropyridin-2(1H)-ones and Quinolin-2(1H)-ones.
J. Org. Chem. 2020, 85 (18), 11867–11881. DOI: 10.1021/acs.joc.0c01623

Přibylka, A.; Krchňák, V.; Schütznerová, E.
Environmentally Friendly SPPS II: Scope of Green Fmoc Removal Protocol Using NaOH and Its Application for Synthesis of Commercial Drug Triptorelin.
J. Org. Chem. 2020, 85 (14), 8798-8811. DOI: 10.1021/acs.joc.0c00599

Jorda, R.; Krajčovičová, S.; Králová, P.; Soural, M.; Kryštof, V.
Scaffold hopping of the SYK inhibitor entospletinib leads to broader targeting of the BCR signalosome
Eur. J. Med. Chem. 2020, 204 (-), 112636. DOI: 10.1016/j.ejmech.2020.112636

Rehulka, J.; Vychodilova, K.; Krejci, P.; Gurska, S.; Hradil, P.; Hajduch, M.; Dzubak, P.; Hlavac, J.
Fluorinated Derivatives of 2-Phenyl-3-Hydroxy-4(1H)-Quinolinone as Tubulin Polymerization Inhibitors.
Eur. J. Med. Chem. 2020, 192 (-), 192, 112176. DOI: 10.1016/j.ejmech.2020.112176.

Šlachtová, V.; Šebela, M.; Torfs, E.; Oorts, L.; Cappoen, D.; Berka, K.; Bazgier, V.; Brulíková, L.*
Novel thiazolidinedione-hydroxamates as inhibitors of Mycobacterium tuberculosis virulence factor Zmp1
Eur. J. Med. Chem. 2020, 185 (-), 111812 (1-13). DOI: 10.1016/j.ejmech.2019.111812

de Jong, F.; Pokorny, J.; Manshian, B.; Daelemans, B.; Vandaele, J.; Startek, J. B.; Soenen, S.; Van der Auweraer, M.; Dehaen, W.; Rocha, S.; Silveira-Dorta, G.
Development and Characterization of BODIPY-Derived Tracers for Fluorescent Labeling of the Endoplasmic Reticulum
Dyes and Pigments 2020, 176 (-), 108200. DOI: 10.1016/j.dyepig.2020.108200

Zálešák, F.; Bon, D. J.-Y. D.; Pospíšil, J.
Lignans and Neolignans: plant secondary metabolites as a reservoir of biologically active substances
Pharmacol. Res. 2019, 146 (n/a), 104284(1-27). DOI: 10.1016/j.phrs.2019.104284

Hodoň, J.; Borkova, L.; Pokorny, J.; Kazakova, A.; Urban, M.
Design and synthesis of pentacyclic triterpene conjugates and their use in medicinal research
Eur. J. Med. Chem. 2019, 182 (N/A), Article Number: 111653 (1-25). DOI: 10.1016/j.ejmech.2019.111653

Krajčovičová, S.; Jorda, R.; Hendrychová, D.; Kryštof, V.; Soural, M.
Solid-phase synthesis for thalidomide-based proteolysis-targeting chimeras (PROTAC)
Chem. Commun. 2019, 55 (7), 929-932. DOI: 10.1039/C8CC08716D

Přibylka, A.; Krchňák, V.; Schütznerová, E.
Environmentally friendly SPPS I. Application of NaOH in 2-MeTHF/methanol for Fmoc removal
Green Chem. 2019, 21 (4), 775-779. DOI: 10.1039/c8gc03778g

Zielke, K.; Kováč, O.; Winter, M.; Pospíšil, J.; Waser, M.
Enantioselective Catalytic [4+1]‐Cyclization of ortho‐Hydroxy‐para‐Quinone Methides with Allenoates
Chem. Eur. J. 2019, 25 (34), 8163-8168. DOI: 10.1002/chem.201901784

Cankařová, N.; Schütznerová, E.; Krchňák, V.
Traceless Solid-Phase Organic Synthesis
Chem. Rev. 2019, 119 (24), 12089-12207. DOI: 10.1021/acs.chemrev.9b00465

Cankařová, N.; La Venia, A.; Krajčovičová, S.; Krchňák, V.
Configuration-Dependent Medium-Sized Ring Formation: Chiral Molecular Framework with Three-Dimensional Architecture
J. Org. Chem. 2019, 84 (2), 636-644. DOI: 10.1021/acs.joc.8b02465

Kriegelstein, M.; Profous, D.; Lyčka, A.; Trávníček, Z.; Přibylka, A.; Volná, T.; Benická, S.; Cankař, P.
Axially Chiral Trifluoromethylbenzimidazolylbenzoic Acid: A Chiral Derivatizing Agent for α-Chiral Primary Amines and Secondary Alcohols To Determine the Absolute Configuration
J. Org. Chem. 2019, 84 (18), 11911-11921. DOI: 10.1021/acs.joc.9b01770

Zhu, Q.; Gallemí, M.; Pospíšil, J.; Žádníková, P.; Strnad, M.; Benková, E.
Root gravity response module guides differential growth determining both root bending and apical hook formation
Development 2019, 146 (17), dev175919. DOI: 10.1242/dev.175919

Spáčilová, P.; Kvasnica, M.; Urban, M.; Hajdúch, M.; Šarek, J.
2‑Deoxyglycoside Conjugates of Lupane Triterpenoids with High Cytotoxic Activity – Synthesis, Activity, and Pharmacokinetic Profile
Bioconjugate Chem. 2019, 30 (11), 2844-2858. DOI: 10.1021/acs.bioconjchem.9b00565

Tomanová, M.; Jedinák, L.; Cankař, P.
Reductive dehalogenation and dehalogenative sulfonation of phenols and heteroaromatics with sodium sulfite in an aqueous medium
Green Chem. 2019, 21 (10), 2621-2628. DOI: 10.1039/c9gc00467j

Vanda, D.; Zajdel, P.; Soural, M.
Imidazopyridine-based selective and multifunctional ligands of biological targets associated with psychiatric and neurodegenerative diseases
Eur. J. Med. Chem. 2019, 181 (-), 111569. DOI: 10.1016/j.ejmech.2019.111569

Bon, D. J.-Y. D; Kováč, O.; Ferugová, V.; Zálešák, F.; Pospíšil, J.
One and two-carbon homologation of primary and secondary alcohols to corresponding carboxylic esters using β-carbonyl BT sulfones as a common intermediate
J. Org. Chem. 2018, 83 (9), 4990-5001. DOI: 10.1021/acs.joc.8b00112

Burglova, K.; Rylova, G.; Markos, A.; Prichystalova, H.; Soural, M.; Petracek, M.; Medvedikova, M.; Tejral, G.; Sopko, B.; Hradil, P.; Dzubak, P.; Hajduch, M.; Hlavac, J.
Identification of Eukaryotic Translation Elongation Factor 1-α 1 Gamendazole-Binding Site for Binding of 3-Hydroxy-4(1H)-quinolinones as Novel Ligands with Anticancer Activity
J. Med. Chem. 2018, 61 (7), 3027-3036. DOI: 10.1021/acs.jmedchem.8b00078

Okorochenkova, Y; Porubsky, M.; Benicka, S.; Hlavac, J.
A novel three-fluorophore system as a ratiometric sensor for multiple protease detection
Chem. Commun. 2018, 54 (55), 7589-7592. DOI: 10.1039/c8cc01731j

Krajčovičová, S.; Staňková, J.; Džubák, P.; Hajdúch, M.; Soural, M.; Urban, M.
Synthetic approach for rapid preparation of BODIPY conjugates and their use in imaging of cellular drug uptake and distribution
Chem. Eur. J. 2018, 24 (19), 4957-4966. DOI: 10.1002/chem.201706093

Schütznerová, E.; Oliver, A. G.; Přibylka, A.; Krchňák, V.
Solid‐Phase Synthesis of Tetramic Acid via Resin‐Bound Enol Ethers as a Privileged Scaffold in Drug Discovery
Adv. Synt.Catal. 2018, 360 (19), 3693-3699. DOI: 10.1002/adsc.201800645

Konrádová, D.; Bon, D. J.-Y. D.; Pospíšil, J.
1-(Phenylsulfonyl)-3-oxabicyclo[3.1.0]hexan-2-one as a building block in organic synthesis
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Bon, D. J.-Y. D.; Mander, L. N.; Lan, P.
Syntheses of Gibberellins A15 and A24, the Key Metabolites in Gibberellin Biosynthesis
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Vanda, D.; Soural, M.; Canale, V.; Chaumont-Dubel, S.; Satała, G.; Kos, T.; Funk, P.; Fülöpová, V.; Lemrová, B.; Koczurkiewicz, P.; Pękala, E.; Bojarski, A.J.; Popik, P.; Marin, P.; Zajdel, P.
Novel non-sulfonamide 5-HT6 receptor partial inverse agonist in a group of imidazo[4,5-b]pyridines with cognition enhancing properties
Eur. J. Med. Chem. 2018, 144 (-), 716-729. DOI: 10.1016/j.ejmech.2017.12.053

Kloss, F.; Krchňák, V.; Krchňáková, A.; Schieferdecker, S.; Dreisbach, J.; Krone, V.; Möllmann, U.; Hoelscher, M.; Miller, M. J.
In Vivo Dearomatization of the Potent Antituberculosis Agent BTZ043 via Meisenheimer Complex Formation
Angew. Chem. Int. Ed. 2017, 56 (8), 2187-2191. DOI: 10.1002/anie.201609737

Plačková, L.; Oklestková, J.; Pospíšková, K.; Poláková, K.; Buček, J.; Stýskala, J.; Zatloukal, M.; Šafařík, I.; Zbořil, R.; Strnad, M.; Doležal, K.,
Microscale magnetic microparticle-based immunopurification of cytokinins from Arabidopsis root apex
The Plant Journal 2017, 89 (5), 1065-1075. DOI: 10.1111/tpj.13443

Schütznerová, E.; Oliver, A.; Slough, G. A.; Krchňák, V.
Traceless Solid-Phase Synthesis of Fused Chiral Macrocycles via Conformational Constraint-Assisted Cyclic Iminium Formation
Chem. Eur. J. 2017, 21 (37), 12876-12885. DOI: 10.1002/chem.201702461

Krajčovičová, S.; Gucký, T.; Hendrychová, D.; Kryštof, V.; Soural, M.
A Stepwise Approach for the Synthesis of Folic Acid Conjugates with Protein Kinases Inhibitors
J. Org. Chem. 2017, 82 (24), 13530-13541. DOI: 10.1021/acs.joc.7b02650

Ručil, T.; Trávníček, Z.; Cankař, P.
Ring-Opening Reactions of the N-4-Nosyl Hough–Richardson Aziridine with Nitrogen Nucleophiles
J. Org. Chem. 2017, 82 (1), 723-730. DOI: 10.1021/acs.joc.6b01942

Jedinák, L.; Zátopková, R.; Zemánková, H.; Šustková, A.; Cankař, P.
The Suzuki–Miyaura Cross-Coupling Reaction of Halogenated Aminopyrazoles: Method Development, Scope, and Mechanism of Dehalogenation Side Reaction
J. Org. Chem. 2017, 82 (1), 157-169. DOI: 10.1021/acs.joc.6b02306

Eignerová, B.; Tichý, M.; Krasulová, J.; Kvasnica, M.; Rárová, L.; Christová, R.; Urban, M.; Bednarczyk-Cwynar, B.; Hajduch, M.; Sarek, J.
Synthesis and antiproliferative properties of new hydrophilic esters of triterpenic acids
Eur. J. Med. Chem. 2017, 140 (-), 403-420. DOI: 10.1016/j.ejmech.2017.09.041

Schütznerová, E.; Krchňák, V.
N-Oxide as an Intramolecular Oxidant in the Baeyer-Villiger Oxidation: Synthesis of 2-Alkyl-2H-indazol-3-yl Benzoates and 2-Alkyl-1,2-dihydro-3H-indazol-3-ones
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Perlíková, P.; Rylová, G.; Nauš, P.; Elbert, T.; Tloušťová, E.; Bourderioux, A.; Poštová Slavětínská, L.; Motyka, K.; Doležal, D.; Znojek, P.; Nová, A.; Harvanová, M.; Džubák, P.; Šiller, M.; Hlaváč, J.; Hajdúch, M.; Hocek, M.
7-(2-Thienyl)-7-Deazaadenosine (AB61), a New Potent Nucleoside Cytostatic with a Complex Mode of Action
Mol. Cancer. Ther. 2016, 15 (5), 922-937. DOI: 10.1158/1535-7163.MCT-14-0933

Carbain, B.; Schütznerová, E.; Přibylka, A.; Krchňák, V.
Solid-Phase Synthesis of 3,4-Dihydroquinoxalin-2(1H)-ones via the Cyclative Cleavage of N-Arylated Carboxamides
Adv. Synth. Catal. 2016, 358 (5), 701-706. DOI: 10.1002/adsc.201500826

Burglova, K.; Okorochenkov, S.; Hlavac, J.
Efficient route to deuterated aromatics by the deamination of anilines
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Jedináková, P.; Šebej, P.; Slanina, T.; Klán, P.; Hlaváč, J.
Study and application of noncatalyzed photoinduced conjugation of azides and cycloocta-1,2,3-selenadiazoles
Chem. Commun. 2016, 52 (-), 4792-4795. DOI: 10.1039/C6CC01789D

Borková, L.; Gurská, S.; Džubák, P.; Buriánová, R.; Hajdúch, M.; Šarek, J.; Popa, I.; Urban, M.
Lupane and 18a-oleanane derivatives substituted in the position 2, their cytotoxicity and influence on cancer cells
Eur. J. Med. Chem. 2016, 121 (-), 120-131. DOI: 10.1016/j.ejmech.2016.05.029

Kvasnica, M.; Urban, M.; Dickinson, N. J.; Šarek, J.
Pentacyclic triterpenoids with nitrogen and sulfur containing heterocycles: Synthesis and medicinal significance
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Ventosa-Andrés, P.; La-Venia, A.; Ripoll, C.A.B.; Hradilová, L.; Krchňák, V.
Synthesis of Nature-Inspired Medium-Sized Fused Heterocycles from Amino Acids
Chem. Eur. J. 2015, 21 (37), 13112-13119. DOI: 10.1002/chem.201501746

Fülöpová, V.; Krchňáková, A.; Schütznerová, E.; Zajíček, J.; Krchňák, V.
Ring Contraction of 2,5-Dihydrobenzo[f][1,2,5]thiadiazepine 1,1-Dioxides: Access to 4H‑Benzo[b][1,4]thiazine 1,1-Dioxides
J. Org. Chem. 2015, 80 (3), 1795-1801. DOI: 10.1021/jo502713k

Okorochenkov, S.; Burglová, K.; Popa, I.;Hlaváč, J.
Solid-Supported Hydrazone of 4-(4′-Formyl-3′-methoxyphenoxy)butyric Acid As a New Traceless Linker for Solid-Phase Synthesis
Org. Lett. 2015, 17 (2), 180-183. DOI: 10.1021/ol5034223

Lee, M; Rucil, T; Hesek, D; Oliver, A. G; Fisher, J. F; Mobashery, S.
Regioselective Control of the SNAr Amination of 5-Substituted-2,4-Dichloropyrimidines Using Tertiary Amine Nucleophiles
J. Org. Chem. 2015, 80 (15), 7757-7763. DOI: 10.1021/acs.joc.5b01044

Soural, M.; Hodon, J.; Dickinson, N.J.; Sidova, V.; Gurska, S.; Dzubak, P.; Hajduch, M.; Sarek, J.; Urban, M.
Preparation of conjugates of cytotoxic lupane triterpenes with biotin
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