Autor: Kvasnica, M.; Urban, M.; Dickinson, N. J.; Šarek, J.
Název práce v češtině: Pentacyklické triterpenoidy s kyslíkatými a dusíkatými heterocykly: Syntéza a medicínské aplikace
Název práce v angličtině: Pentacyclic triterpenoids with nitrogen and sulfur containing heterocycles: Synthesis and medicinal significance
Studentská publikace: ne
Klíčová slova v češtině: Triterpeny, heterocykly, syntéza
Klíčová slova v angličtině: triterpenoids, heterocycles, synthesis, activity
Abstrakt česky: Triterpenoidy jsou zajímavou skupinou přírodních látek, sekundárních metabolitů. Toto review zahrnuje heterocyklické deriváty, jejich syntézu a biologické aktivity a pokrývá tuto oblast chemie od roku 1962 do 2014.
Abstrakt anglicky: Triterpenoids are natural compounds with a variety of biological activities and are usually produced by plants as secondary metabolites. In the recent decades, scientists focused on triterpenoid properties discovered many activities such as antitumor, antiviral, antimicrobial, anti-inflammatory and others. Thousands of new triterpenoids with various skeletal modifications have been synthesized by now. One of the most important modifications is the formation of a new heterocyclic ring. The simple fact that the vast majority of currently used drugs are heterocyclic compounds encouraged a lot of researches to synthesize analogous triterpenoid derivatives in order to find new molecules with higher activities and consequently optimize their pharmacological profile. Biological properties of triterpenoid heterocycles are very promising and many of them have been studied especially as antitumor agents. This review is mainly focused on the synthesis of various types of nitrogen and occasionally sulfur containing heterocyclic triterpenoids for their potential use as future drugs in medicine and in addition discusses their overall biological activities.
Jazyk v originále: Anglický
Název časopisu: Nat. Prod. Rep.
Rok: 2015
Svazek (ročník): 32
Číslo časopisu v rámci uvedeného svazku: 9
Strana od-do: 1303-1330
Impact factor: 10.986
Q1: ne

ISSN časopisu: 0265-0568
Vydavatel: Royal Society of Chemistry
Způsob financování: Fund (CZ.1.07/2.3.00/30.0060) GJ15-08202Y, GA15-05620S, LO1304, LO1204
DOI: 10.1039/c5np00015g