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Liška, A.; Chrenko, D.; Zatloukalová, M.; Klíma, J.; Papoušková, B.; Kabeláč, M.; Ludvík, J.; Pospíšil, J.; Vacek, J.
Redox Behaviour of Nitro-Fatty Acids and Their Ester
Electrochimica Acta 2026, 545 (n/a), 147698 (p. 1-12). DOI: 10.1016/j.electacta.2025.147698

Profous, D.; Cankařová, N.; Enengl, J.; Soji, S.; Rinner, U.; Jurečka, P.; Cankař, P.
Second-Generation Synthesis and Analytical Application of TBBA for Chiral Analysis of Amino Acids and Oligopeptides by 1H and 19F NMR Spectroscopy
J. Org. Chem. 2026, 91 (5), 2065-2073. DOI: 10.1021/acs.joc.5c02693

Orság, Š.; Frydrych, I.; Lišková, B.; Gurská, S.; Přibylka, A.; Hodoň, J.; Džubák, P.; Hajdúch, M. Urban, M.
Synthesis and biological evaluation of novel C-30 modified lupane triterpenoids selectively cytotoxic against cancer cells
Eur. J. Med. Chem. 2026, 302 ((-)), 118268. DOI: 10.1016/j.ejmech.2025.118268

Profous, D.; Kriegelstein, M.; Jurečka, P.; Cankař, P.
Application of 19F NMR Spectroscopy for Determining the Absolute Configuration of α‑Chiral Amines and Secondary Alcohols Using Trifluoromethylbenzoimidazolylbenzoic Acid
J. Org. Chem. 2025, 90 (28), 9867-9884. DOI: 10.1021/acs.joc.5c00879

Lemrová, B.; Žáková, K.; Soural, M.
Synthesis of Imidazo[2,1-a]isoindolones via Rearrangement and Tandem Cyclization of Amino Acid-based N-Phenacyl-2-cyano-4-nitrobenzensulfonamides
J. Org. Chem. 2025, 90 (22), 7151-7160. DOI: doi.org/10.1021/acs.joc.4c03113

Krajcovicova, S.; Wharton, T.; Driscoll, C. L.; King, T. A.; Howarth, M. R.; Spring, D. R.
A Platform for SpyCatcher Conjugation to Native Antibodies
Chemical Science 2025, 2025 (16), 10602-10609. DOI: https://doi.org/10.1039/D5SC02286J

Müller, N.; Magauer, T.; Kováč, O.
Natural Product Synthesis Enabled by Radical-Polar Crossover Reactions
J. Org. Chem. 2025, 90 (15), 5083-5092. DOI: https://doi.org/10.1021/acs.joc.5c00306

Chrenko, D.; Pereckova, J.; Zatloukalová, M.; Vacek, J.; Pospíšil*, J.; Perecko*, T.
Regio- and Stereoselective Synthesis of Nitro-fatty Acids as NRF2Pathway Activators Working under Ambient or Hypoxic Conditions
J. Med. Chem. 2025, 68 (11), 12172-12184. DOI: 10.1021/acs.jmedchem.5c00982

Toman, D.; Nemec, I.; Kurka, O.; Přibylka, A.; Cankař, P.
Axially chiral dimethylaminobenzimidazoles and their preliminary evaluation as acyl-transfer reagents
Org. Biomol. Chem. 2025, 23 (11), 2672-2682. DOI: 10.1039/D4OB02052A

Kazakova, A.; Frydrych, I.; Jakubcová, N.; Pokorný, J.; Lišková, B.; Gurská, S.; Buriánová, R.; Přibylka, A.; Džubák, P.; Hajdúch, M.; Urban, M.
Triterpenoid phthalimides as selective anti-cancer agents targeting mitochondrial apoptosis
Eur. J. Med. Chem. 2025, 283 (-), 117126 (1-23). DOI: 10.1016/j.ejmech.2024.117126

Chasák, J.; Janicki, I.; Brulíková, L.*
The Liebeskind–Srogl cross-coupling reaction towards the synthesis of biologically active compounds
Eur. J. Med. Chem. 2025, 290 (-), 117526. DOI: 10.1016/j.ejmech.2025.117526

Salaga, M.; Binienda, A.; Canale, V. ; Grychowska, K.; Soural, M.; Marin, P.; Zajdel , P.
Serotonin type 6 receptor inverse agonists and neutral antagonists inhibit defecation: relevance to intestinal motility disorders
Eur. J. Pharmacol. 2025, 1005 (-), 178099-178105. DOI: 10.1016/j.ejphar.2025.178099

Zůvalová, I.; Grycová, A.; Hrubý, J.; Illes, P.; Soural, M.; Kováč, O.; Šebela, M.; Bachleda, P.; Kriegová, E.; Trajerová, M.; Dvořák, Z.
Methylcarvones as immunomodulators through antagonism of aryl hydrocarbon receptor
Bioorg. Chem. 2025, 167 (-), 109256-109265. DOI: doi.org/10.1016/j.bioorg.2025.109256

Zůvalová, I.; Vyhlídalová, B.; Ondrová, K..; Nádvorník, P.; Hrubý, J.; Illés, P.; Soural, M.; Šebela, M.; Šindlerová, L.; Kubala, L.; Mani, S.; Dvořák, Z.
Decoding structural determinants of aryl hydrocarbon receptor antagonism by monoterpenoids
Bioorg. Chem. 2025, – (-), 108265. DOI: doi.org/10.1016/j.bioorg.2025.108265

Kolařík, M.; Ilbeigi, K.; Caljon, G.; Brulíková, L.*
Thiazolidinones and related analogues as efficient antitrypanosomal agents
Bioorg. Med. Chem. 2025, 130 (-), 118363. DOI: 10.1016/j.bmc.2025.118363

Kazakova, A.; Frydrych, I.; Jakubcová, N; Pokorný. J.; Lišková, B.; Gurská, S.; Džubák, P.; Hajdúch, M.; Urban, M.
Novel triterpenoid pyrones, phthalimides and phthalates are selectively cytotoxic in CCRF-CEM cancer cells – Synthesis, potency, and mitochondrial mechanism of action
Eur. J. Med. Chem. 2024, 269 (N/A), 116336 (1-16). DOI: 10.1016/j.ejmech.2024.116336

Petřík, I.; Pěnčík, A.; Stýskala, J.; Tranová, L.; Amakorová; P.; Strnad, M.; Novák, O.
Rapid profiling of cytokinins using supercritical fluid chromatography coupled with tandem mass spectrometry
Analytica Chimica Acta 2024, 1258 (n/a), 342010(1-10). DOI: 10.1016/j.aca.2023.342010

Rode, A.; Müller, N.; Kováč, O.; Wurst, K.; Magauer, T.
A General Entry to Ganoderma Meroterpenoids: Synthesis of Applanatumol E, H, and I, Lingzhilactone B, Meroapplanin B, and Lingzhiol
Org. Lett. 2024, 26 (42), 9017-9021. DOI: https://doi.org/10.1021/acs.orglett.4c03192

Pospíšilová, J.; Heger, T.; Kurka, O.; Kvasnicová, M.; Chládková, A.; Nemec, I.; Rárová, L.; Cankař, P.
Atropisomeric 1-phenylbenzimidazoles affecting microtubule organization: influence of axial chirality
Org. Biomol. Chem. 2024, 22 (34), 6966-6980. DOI: 10.1039/D4OB00863D

Müller, N.; Kováč, O.; Rode, A.; Atzl, D.; Magauer, T.*
Total Synthesis of Ganoapplanin Enabled by a Radical Addition/Aldol Reaction Cascade
J. Am. Chem. Soc. 2024, 146 (33), 22937-22942. DOI: https://doi.org/10.1021/jacs.4c08291

Bon, D.J.-Y. D.; Chrenko, D.; Kováč, O.; Ferugová, V.; Lasák, P.; Fuksová, M.; Zálešák, F.; Pospíšil, J.;
Julia-Kocienski-like connective C-C and C=C bond-forming reaction
Adv. Synth. Cat. 2024, 366 (3), 480-487. DOI: 10.1002/adsc.202301054

Porubsky, M. ; Hodon, J. ; Stanková, J.; Dzubák, P., ; Hajdúch, M. ; Urban, M.; Hlavác, J.
Near-infrared pH-switchable BODIPY photosensitizers for dual biotin/ cRGD targeted photodynamic therapy
Journal of Photochemistry and Photobiology B-Biology 2024, 2024 (259), 113010. DOI: 10.1016/j.jphotobiol.2024.113010

Žáková, K.; Králová, P.; Soural, M.
Synthesis of 2-amino-3-arylindoles and their fused analogues via intramolecular C-arylation
Adv. Synth. Catal. 2024, 366 (11), 2519-2526. DOI: 10.1002/adsc.202400143

Králová, P.; Soural, M.
Biological properties of pyrroloquinoline and pyrroloisoquinoline derivatives
Eur. J. Med. Chem 2024, 269 (-), 116287 (1-42). DOI: doi.org/10.1016/j.ejmech.2024.116287

Sydenham J. D. ; Seki, H.; Krajcovicova, S.; Schober, T.; Zeng, L.; Deingruber, T. ; Spring D. R.
Site-Selective Peptide Functionalisation Mediated via Vinyl-Triazine Linchpins
Chem. Commun. 2024, 60 (-), 706-709. DOI: 10.1039/D3CC05213C

Krajcovicova, S.
Ideas Behind the Tryptophan-Mediated Petasis Reaction (TMPR) Concept for Peptide Stapling
ChemMedChem 2024, 19 (-), e202400148. DOI: https://doi.org/10.1002/cmdc.202400148

Tkadlecová, M.; Lemrová, B.; Soural, M.
Synthesis of Polysubstituted Pyridines and Pyrazines via Truce-Smiles Rearrangement of Amino Acid-based 4-Nitrobenzenesulfonamides
J. Org. Chem. 2023, 88 (5), 3228-3237. DOI: 10.1021/acs.joc.2c03025

Tomanová, M.; Vaňková, I.; Toman, D.; Přibylka, A.; Nemec, I.; Cankař, P.
Axially Chiral Sulfonic Acids for Brønsted Acid Catalysis: 8-Benzoimidazolylnaphthalene-1-sulfonic Acids and Their Derivatives
J. Org. Chem. 2023, 88 (13), 9265–9276. DOI: 10.1021/acs.joc.3c00818

Krajcovicova, S.*; Spring, D. R.
Tryptophan in Multicomponent Petasis Reactions for Peptide Stapling and Late-Stage Functionalisation
Angew. Chem. Int. Ed. 2023, 62 (-), e202307782. DOI: 10.1002/anie.202307782

Iegre, J.‡; Krajcovicova, S.‡; Gunnarsson, A.; Wissler, L.; Kaeck, H.; Luchniak, A.; Tangefjord, S.; Narjes, F.; Spring, D. R.
A cell-active cyclic peptide targeting the Nrf2/Keap1 protein–protein interaction
Chem. Sci. 2023, 14 (-), 10800-10805. DOI: 10.1039/D3SC04083F

King, T.; Walsh, S.; Kapun, M.; Wharton, T.; Krajcovicova, S.; Glossop, M.; Spring, D. R.
Disulfide re-bridging reagents for single-payload antibody-drug conjugates
Chem. Commun. 2023, 59 (-), 9868-9871. DOI: 10.1039/D3CC02980H

Chasák, J.; Oorts, L.; Dak, M.; Šlachtová, V.; Bazgier, V.; Berka, K.; De Vooght, L.; Smiejkowska, N.; Van Calster, K.; Van Moll, L.; Cappoen, D.; Cos, P.; Brulíková, L.*
Expanding the squaramide library as mycobacterial ATP synthase inhibitors: innovative synthetic pathway and biological evaluation
Bioorg. Med. Chem. 2023, 95 (-), 117504(1-18). DOI: 10.1016/j.bmc.2023.117504

Supiková, K.; Kosinová, A.; Vavruša, M.; Kopliková, L.; Francois, A.; Pospíšil, J.; Zatloukal, M.; Wever, R.; Hartog, A.; Grúz, J.
Sulfated phenolic acids in plants
Planta 2022, 255 (na), 124 (1-12). DOI: 10.1007/s00425-022-03902-6

Králová, P.; Soural, M.
Synthesis of Polycyclic Tetrahydroisoquinolines and Tetrahydrobenzo[d]azepines from Polymer-Supported Allylglycine
J. Org. Chem. 2022, 87 (8), 5242–5256. DOI: 10.1021/acs.joc.2c00039

Matvieiev, O.; Šelešovská, R.; Vojs, M.; Marton, M.; Michniak, P.; Hrdlička, V.; Hatala, M.; Janíková, L.; Chýlková, J.; Skopalová, J.; Cankař, P.; Navrátil, T.
Novel Screen-Printed Sensor with Chemically Deposited Boron-Doped Diamond Electrode: Preparation,Characterization, and Application
Biosensors 2022, 12 (4), 241(1-21). DOI: 10.3390/bios12040241

Tomanová, M.; Kozlanská, K.; Jorda, R.; Jedinák, L.; Havlíková, T.; Řezníčková, E.; Peřina, M.; Klener, P.; Dolníková, A.; Cankař, P.; Kryštof, V.
Synthesis and Structural Optimization of 2,7,9-Trisubstituted purin-8-ones as FLT3-ITD Inhibitors
Int. J. Mol. Sci. 2022, 23 (24), 16169. DOI: 10.3390/ijms232416169

Cankařová, N.*; Nemec, I.; Krchňák, V.
p-TSA-Mediated Four-Component Reaction: One-Step Access to Mesoionic 1H-Imidazol-3-ium-4-olates, Direct NHC Precursors
Adv. Synth. Catal. 2022, 364 (-), 2996-3003. DOI: 10.1002/adsc.202200398

Zálešák, F.; Kováč, O.; Lachetová, E.; Šťastná, N.; Pospíšil,J.
Unified approach to benzo[d]thiazol-2-yl-sulfonamides
J. Org. Chem. 2021, 86 (17), 11291-11309. DOI: 10.1021/acs.joc.1c00317

Králová, P.; Soural, M.
Reagent-Based Diversity-Oriented Synthesis of Triazolo[1,5-a][1,4]diazepine Derivatives from Polymer-Supported Homoazidoalanine
J. Org. Chem. 2021, 86 (12), 7963-7974. DOI: 10.1021/acs.joc.1c00293

Tan, S.; Abas, M.; Verstraeten, I.; Glanc, M.; Molnár, G.; Hajný, J.; Lasák, P.; Petřík, I.; Russinova, E.; Petrášek, J.; Novák, O.; Pospíšil, J.; Friml, J.*
Salicylic Acid Targets Protein Phosphatase 2A to Attenuate Growth in Plants
Curr. Biol. 2020, 30 (n/a), 381-395. DOI: 10.1016/j.cub.2019.11.058

Kováč, O.; Zálešák, F.; Bon, D.J.-Y.D; Roiser, L.; Baar, L.V.; Waser, M.; Pospíšil, J.
risubstituted highly activated benzo[d]thiazol-2-yl-sulfone-containing olefins as building blocks in organic synthesis
J. Org. Chem. 2020, 85 (n/a), 7192-7206. DOI: 10.1021/acs.joc.0c00571

Mathieu, A.S.; Dobrev, P.I.; Tarkowská, D.; Pospíšil, J.; Motyka, V.; Jacquemin, G.; Quinet, M.; Lutts, S.
Phytohormone profile and CiFL1 expression in young seedlings of Cichorium intybus L. var sativum exposed to high temperature in relation to vernalization and de-vernalization processes
Environ. Exp. Bot. 2020, 178 (n/a), 104127 (1-13). DOI: 10.1016/j.envexpbot.2020.104127

Vacek, J.; Zatloukalová, M.; Vrba, J.; De Vleeschouwer, F.; De Proft, F.; Obluková, M.; Sokolová, R.; Pospíšil, J.
Diferulate: A highly effective electron donor
J. Electroanal. Chem. 2020, 865 (n/a), 113950 (1-7). DOI: https://doi.org/10.1016/j.jelechem.2020.113950

Šelešovská, R.; Hlobeňová, F.; Skopalová, J.; Cankař, P.; Janíková, L.; Chýlková, J.
Electrochemical oxidation of anti-inflammatory drug meloxicam and its determination using boron doped diamond electrode
J. Electroanal. Chem. 2020, 858 (n/a), 113758/1-113758/10. DOI: 10.1016/j.jelechem.2019.113758

Jerga, R.; Rajcová, A.; Müllerová, V.; Barták, P.; Cankař, P.; Navrátil, T.; Skopalová, J.
Phospholipid modified glassy carbon electrode for determination of chili peppers pungency by ex-situ extraction voltammetry
J. Electroanal. Chem. 2020, 858 (n/a), 113790/1-113790/9. DOI: 10.1016/j.jelechem.2019.113790

Cankařová, N.*; Krchňák, V.
Isocyanide Multicomponent Reactions on Solid Phase: State of the Art and Future Application
Int. J. Mol. Sci. 2020, 21 (23), 9160 (1-48). DOI: 10.3390/ijms21239160

Kriegelstein, M.; Profous, D.; Přibylka, A.; Cankař, P.
The Assignment of the Absolute Configuration of β-Chiral Primary Alcohols with Axially Chiral Trifluoromethylbenzimidazolylbenzoic Acid
J. Org. Chem. 2020, 85 (20), 12912–12921. DOI: 10.1021/acs.joc.0c01510

Králová, P.; Maloň, M.; Pospíšil, J.; Soural, M.
Rearrangement of Threonine and Serine-Based N-(3-Phenylprop-2-yn-1-yl) Sulfonamides Yields Chiral Pyrrolidin-3-ones
J. Org. Chem. 2020, 85 (2), 985-993. DOI: 10.1021/acs.joc.9b02932

Jorda, R.; Krajčovičová, S.; Králová, P.; Soural, M.; Kryštof, V.
Scaffold hopping of the SYK inhibitor entospletinib leads to broader targeting of the BCR signalosome
Eur. J. Med. Chem. 2020, 204 (-), 112636. DOI: 10.1016/j.ejmech.2020.112636

Zálešák, F.; Bon, D. J.-Y. D.; Pospíšil, J.
Lignans and Neolignans: plant secondary metabolites as a reservoir of biologically active substances
Pharmacol. Res. 2019, 146 (n/a), 104284(1-27). DOI: 10.1016/j.phrs.2019.104284

Zielke, K.; Kováč, O.; Winter, M.; Pospíšil, J.; Waser, M.
Enantioselective Catalytic [4+1]‐Cyclization of ortho‐Hydroxy‐para‐Quinone Methides with Allenoates
Chem. Eur. J. 2019, 25 (34), 8163-8168. DOI: 10.1002/chem.201901784

Cankařová, N.; Schütznerová, E.; Krchňák, V.
Traceless Solid-Phase Organic Synthesis
Chem. Rev. 2019, 119 (24), 12089-12207. DOI: 10.1021/acs.chemrev.9b00465

Cankařová, N.; La Venia, A.; Krajčovičová, S.; Krchňák, V.
Configuration-Dependent Medium-Sized Ring Formation: Chiral Molecular Framework with Three-Dimensional Architecture
J. Org. Chem. 2019, 84 (2), 636-644. DOI: 10.1021/acs.joc.8b02465

Kriegelstein, M.; Profous, D.; Lyčka, A.; Trávníček, Z.; Přibylka, A.; Volná, T.; Benická, S.; Cankař, P.
Axially Chiral Trifluoromethylbenzimidazolylbenzoic Acid: A Chiral Derivatizing Agent for α-Chiral Primary Amines and Secondary Alcohols To Determine the Absolute Configuration
J. Org. Chem. 2019, 84 (18), 11911-11921. DOI: 10.1021/acs.joc.9b01770

Zhu, Q.; Gallemí, M.; Pospíšil, J.; Žádníková, P.; Strnad, M.; Benková, E.
Root gravity response module guides differential growth determining both root bending and apical hook formation
Development 2019, 146 (17), dev175919. DOI: 10.1242/dev.175919

Tomanová, M.; Jedinák, L.; Cankař, P.
Reductive dehalogenation and dehalogenative sulfonation of phenols and heteroaromatics with sodium sulfite in an aqueous medium
Green Chem. 2019, 21 (10), 2621-2628. DOI: 10.1039/c9gc00467j

Schütznerová, E.; Přibylka, A.; Krchňák, V.
Nα-Amino acid containing privileged structures: design, synthesis and use in solid-phase peptide synthesis
Org. Biomol. Chem. 2018, 16 (29), 5359-5362. DOI: 10.1039/c8ob01485j

Schütznerová, E.; Oliver, A. G.; Přibylka, A.; Krchňák, V.
Solid‐Phase Synthesis of Tetramic Acid via Resin‐Bound Enol Ethers as a Privileged Scaffold in Drug Discovery
Adv. Synt.Catal. 2018, 360 (19), 3693-3699. DOI: 10.1002/adsc.201800645

Tomanová, M.; Jedinák, L.; Košař, J.; Kvapil, L.; Hradil, P.; Cankař, P.
Synthesis of 4-substituted pyrazole-3,5-diamines via Suzuki–Miyaura coupling and iron-catalyzed reduction
Org. Biomol. Chem. 2017, 15 (48), 10200–10211. DOI: 10.1039/c7ob02373a

Ručil, T.; Trávníček, Z.; Cankař, P.
Ring-Opening Reactions of the N-4-Nosyl Hough–Richardson Aziridine with Nitrogen Nucleophiles
J. Org. Chem. 2017, 82 (1), 723-730. DOI: 10.1021/acs.joc.6b01942

Jedinák, L.; Zátopková, R.; Zemánková, H.; Šustková, A.; Cankař, P.
The Suzuki–Miyaura Cross-Coupling Reaction of Halogenated Aminopyrazoles: Method Development, Scope, and Mechanism of Dehalogenation Side Reaction
J. Org. Chem. 2017, 82 (1), 157-169. DOI: 10.1021/acs.joc.6b02306

Kučerová, P.; Skopalová, J.; Kučera, L.; Táborský, J.; Švecová, H.; Lemr, K.; Cankař, P.; Barták, P.
Electrochemical oxidation of 5-hydroxymethyl tolterodine and identification of its oxidation products using liquid chromatography and mass spectrometry
Electrochim. Acta 2016, 215 (N/A), 617-625. DOI: 10.1016/j.electacta.2016.08.137

Schütznerová, E.; Krchňák, V.
N-Oxide as an Intramolecular Oxidant in the Baeyer-Villiger Oxidation: Synthesis of 2-Alkyl-2H-indazol-3-yl Benzoates and 2-Alkyl-1,2-dihydro-3H-indazol-3-ones
J. Org. Chem. 2016, 81 (9), 3585-3596. DOI: 10.1021/acs.joc.6b00251

Carbain, B.; Schütznerová, E.; Přibylka, A.; Krchňák, V.
Solid-Phase Synthesis of 3,4-Dihydroquinoxalin-2(1H)-ones via the Cyclative Cleavage of N-Arylated Carboxamides
Adv. Synth. Catal. 2016, 358 (5), 701-706. DOI: 10.1002/adsc.201500826

Cankařová, N.; La Venia, A.; Krchňák, V.
Polymer-Supported Stereoselective Synthesis of Tetrahydrobenzopyrazino-thiadiazinone Dioxides via N-Sulfonyl Iminiums
ACS Comb. Sci. 2014, 16 (6), 293-302.

Cankař. P; Popa, I.; Trávníček, Z.; Stýskala, J.; Hradil P.; Slouka, J.
Synthesis of 1-Aminocodeine as a Synthon for Other Codeine Derivatives
Eur. J. Org. Chem. 2013, 2013 (27), 6062-6068.

Cankařová, N.; Krchňák, V.
Polymer-Supported Stereoselective Synthesis of Benzimidazolinopiperazinones
J. Org. Chem. 2012, 77 (13), 5687-5695.