Autor: Brulíková, L.
Název práce v češtině: Nové malé antimykobakteriální molekuly proti drug-rezistentním patogenům
Název práce v angličtině: Novel small molecule antimycobacterials against drug resistant pathogens
Klíčová slova v češtině: tuberkulóza, rezistence, ATP synthasa, Zmp1
Klíčová slova v angličtině:tuberculosis, rezistance, ATP synthase, Zmp1
Abstrakt česky: Zvaná přednáška představila nejnovější poznatky z výzkumné skupiny.
Abstrakt anglicky: Tuberculosis (TB) is a communicable disease caused by bacteria Mycobacteium tuberculosis. Tuberculosis is one of the leading causes of death worldwide. Until the coronavirus (COVID-19) pandemic, TB was the leading cause of death from a single infectious agent, ranking above HIV/AIDS. TB is also leading cause of deaths related to antimicrobial resistance. About one-quarter of the world’s population has a latent TB infection, which means people have been infected by TB bacteria but are not (yet) ill with the disease and cannot transmit it. Although TB is preventable and curable, the alarming increase in drug-resistant tuberculosis cases dramatically complicates the treatment. Reasons for re-emergence and spreading of TB are emergence of drug-resistant bacterial strains, appearance and spreading of hypersusceptible populations. Moreover, in developing countries the treatment is insufficient or completely lacking. For all of these reasons, many researches are interested in devloping novel agents for TB treatment. In my presentation, I talked about one essential target and one non-lethal target.
Jazyk v originále: angličtina
Publikace abstraktu: online
Forma prezentace: invited lecture
Název konference: Highlighting Organic Chemistry in The Czech Republic
Místo konání: online
Datum konání: May 19th
Rok konání: 2023
Způsob financování: IGA_PrF_2021_024, IGA_PrF_2022_022