Autor: Konrádová, D.; Kozubíková, H.; Doležal, K.; Pospíšil, J.
Název práce v češtině: Microwave-Assisted Synthesis of Phenylpropanoids and Coumarins: Total Synthesis of Osthol
Název práce v angličtině: Microwave-Assisted Synthesis of Phenylpropanoids and Coumarins: Total Synthesis of Osthol
Studentská publikace: ne
Klíčová slova v češtině: syntetické metody; kyslíkaté heterocykly; totální syntéza; cyklizace; chemie iniciovaná mikrovlnným zářením
Klíčová slova v angličtině: Synthetic methods; Oxygen heterocycles; Total synthesis; Microwave chemistry; Cyclization
Abstrakt česky: Herein we describe a one-pot microwave-assisted
method for the synthesis of cinnamic acid and coumarin derivatives.
The synthesis begins with an aldehyde synthon, and the
chosen reaction conditions determine whether a cinnamic acid
or coumarin derivative is formed. A regioselective Claisen rearrangement was also efficiently incorporated into the synthetic
sequence to further increase the complexity of the product.
Notably, this approach provides high product yields and selectivities
without the need of a phenol protecting group.
Abstrakt anglicky: A method was developed for the microwave-assisted one-pot synthesis of phenylpropanoids, monolignols, and coumarins. The chosen reaction conditions determine whether a cinnamic acid or coumarin derivative is produced. The optimized reaction conditions were also applied to the synthesis of osthol (13) and several other natural products.
Jazyk v originále: anglicky
Název časopisu: Eur. J. Org. Chem.
Rok: 2017
Svazek (ročník): 2017
Číslo časopisu v rámci uvedeného svazku: 35
Strana od-do: 5204–5213

Q1: ne

ISSN časopisu: 1434-193X (print). 1099-0690 (online).
Vydavatel: WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Způsob financování: Ministry of Education, Youth and Sports of the Czech Republic. Grant Number: LO1204 from the National Program of Sustainability I; Internal Grant Agency of Palacky University. Grant Number: IGA_PrF_2017_013; Internal Grant Agency of Palacky University. Grant Number: IGA_PrF_2017_010
DOI: 10.1002/ejoc.201701021