Autor: Sarek, J.; Kvasnica, M.; Urban, M.;Klinot J.; Hajduch, M.
Název práce v češtině: Korelace Cytotoxicke Aktivity Betulininu a Jejich Hydroxyderivatu
Název práce v angličtině: Correlation of cytotoxic activity of betulinines and their
Studentská publikace: ne

Klíčová slova v angličtině: Triterpenes; Hydrolysis; Acetate; Cytotoxicity
Abstrakt česky: Tento vyzkum je zalozen na snaze pripravit a otestovat 3beta-hydroxy- a 3beta, 28-dihydroxy analoga novych pro apoptotickych derivatu (betulininu)s vyuzitim hydrolytickych procedur a pouzitim strategie selektivnich chranicich skupin. Hodnoceni cytotoxicke aktivity novych sloucenin bylo delano na nekolika nadorovych bunecnych liniich s pouzitim MTT testu. Hydrolyza poskytla derivaty s vyssi aktivitou nez vychozi latky v pripade 18-lupene-21-onu(napr. ethyl 3b-hydroxy-21-oxolup-18-en-28-oatu),zatimco hydrolyza 18-lupene-21,22-dioneu poskytla slouceniny s aktivitou nizsi.““
Abstrakt anglicky: This research is based on intention to prepare and test 3b-hydroxy and 3b,28-dihydroxy analogues of new pro-apoptoticderivatives (betulinines) using selective hydrolysis procedure and strategic protective groups. The evaluation of cytotoxicity of preparedcompounds on several tumor cell lines using an MTT test was our interest. It was found that hydrolysis of acetates in betulininesafforded compounds with higher cytotoxicity in case of 18-lupene-21-ones (e.g., ethyl 3b-hydroxy-21-oxolup-18-en-28-oate),whereas hydrolysis of the 18-lupene-21,22-diones gave less active derivatives),whereas hydrolysis of the 18-lupene-21,22-diones gave less active derivatives““
Jazyk v originále: English
Název časopisu: Bioorganic & Medicinal Chemistry Letters
Rok: 2005
Svazek (ročník): 15

Strana od-do: 4196-4200

Q1: ne

Způsob financování: MSM 6198959216, GACR 203/03/D152 and 301/03/1570, MPO FT-TA/027,