Autor: Kvasnica, M.; Tislerova, I.; Sarek, J.; Sejbal, J.; Cisarova, I.
Název práce v češtině: Příprava nových oxidovaných 18 alfa-oleananových derivátů
Název práce v angličtině: Preparation of new oxidized 18-alpha-oleanane derivatives
Studentská publikace: ne

Klíčová slova v angličtině: triterpenes; triterpenoids; oleanane; oxidation; seco oleanane; H-1 and C-13 NMR spectroscopy; X-ray diffractions

Abstrakt anglicky: 19 beta, 28-Epoxy-4,5-seco-3,5-cyclo-18 alpha-olean-3(5)-ene ( 2) is an appropriate compound for oxidations, which lead to new oxidized compounds with potential biological activities. Several oxidations were used such as epoxidation, allylic oxidation, oxidative cleavage of double bond and other ones. From the starting compound epoxides 3a, 3b and unsaturated ketone 4 were prepared. This ketone was further oxidized to diketone 6 and anhydride 7. The double bonds of all unsaturated compounds were cleaved with ruthenium tetroxide to afford new A-seco oleananes. The structure and stereochemistry of the compounds were derived from IR, MS, H-1 and C-13 NMR spectra (1D and 2D COSY, TOCSY, NOESY, HSQC, HMBC).
Jazyk v originále: angličtina
Název časopisu: Coll. Czech. Chem. Commun.
Rok: 2005
Svazek (ročník): 70
Číslo časopisu v rámci uvedeného svazku: 9
Strana od-do: 1447-1464

Q1: ne