Autor: Urban, M.; Sarek, J.; Tislerova, I.; Dzubak, P.; Hajduch, M.
Název práce v češtině: Vliv esterifikace a modifikace kruhu A lupanových kyselin na jejich cytotoxicitu
Název práce v angličtině: Influence of esterification and modification of A-ring in a group of lupane acids on their cytotoxicity
Studentská publikace: ne

Klíčová slova v angličtině: betulinic acid; esters; cytotoxicity; diosphenols; seco derivatives; cleavage; oxidation

Abstrakt anglicky: The aim of this work was to find an optimal ester group for preparation of lupane derivatives connecting high cytotoxicity with good chemical and pharmacological properties. Activities of methyl-, pivaloyloxymethyl-(Pom-), and acetoxymethyl(Acm-) esters were compared with the activity of free acids. Although the methyl- and Pom-esters were generally less active than free acids, some Acm-esters had cytotoxicity similar to or even better than the starting compounds. Cytotoxic activity was measured in five cancer cell lines. (c) 2005 Elsevier Ltd. All rights reserved.
Jazyk v originále: angličtina
Název časopisu: Bioorganic & Medicinal Chemistry
Rok: 2005
Svazek (ročník): 13
Číslo časopisu v rámci uvedeného svazku: 19
Strana od-do: 5527-5535

Q1: ne