Autor: Hlaváč, J.; Soural, M.; Hradil, P.; Fryšová, I.; Slouka, J.
Název práce v češtině: The cleavage of heterocyclic compounds in organic synthesis II. Use of 5-nitroisatine for synthesis of various nitrogenous heterocycles

Studentská publikace: ne

Abstrakt česky: The reactions of 5-nitroisatine were studied with nucleophiles like heterocyclic amines and alkaline hydroxide. With the use of alkaline hydroxide it was converted into 2-amino-5-nitrophenylglyoxylic acid 2, with piperidine, morpholine and carbethoxypiperazine to its amides 4a-4c or by oxidation to 5-nitroanthranilic acid 7. This acid was used for synthesis of 3-hydroxy-6-nitro-2-phenyl-1H-quinolin-4-one 10. Semicarbazone of 5-nitroisatine 11 was converted to 5-(2-amino-5-nitrophenyl)-2,3,4,5-tetrahydro-1,2,4- triazine-3,5-dione 12. Cyclocondensation of this compound to afford 8-nitro-2,3-dihydro-5H-[1,2,4]triazino-[5,6-b]indol-3-one 13 was unsuccessful.““

Jazyk v originále: čeština
Název časopisu: J. Heterocyclic Chem.
Rok: 2004
Svazek (ročník): 4
Číslo časopisu v rámci uvedeného svazku: 41
Strana od-do: 633-636

Q1: ne