Programme Coordinator:
doc. RNDr. Miroslav Soural, Ph.D.
Summary
The PhD programme in Organic and Bioorganic Chemistry is designed to develop scholars capable of conducting independent, high-level theoretical and experimental research. Graduates possess a comprehensive understanding of organic synthesis and molecular properties, alongside their applications in medicinal chemistry and chemical biology.
Equipped with a robust theoretical foundation across all chemical disciplines, students become proficient in advanced laboratory techniques, database management, and literature review. The curriculum ensures candidates can independently design, synthesise, and analyse novel compounds using state-of-the-art synthetic methods and structural analysis (NMR, mass spectrometry, UV-Vis, IR, and others). Furthermore, a deep understanding of reaction mechanisms enables graduates to approach compound preparation with creative, problem-solving expertise.
Objectives
The primary objective is to produce highly qualified scientists specialising in organic chemistry, bioorganic chemistry, and the development of biologically active compounds.
What you will master
- Advanced Chemical Insights: Gain deep expertise in cutting-edge organic synthesis and the physicochemical properties of molecules, while staying at the forefront of emerging trends in chemical biology.
- Synthetic Innovation: Master the art of synthetic methodology, from unravelling complex reaction mechanisms to executing sophisticated molecular transformations.
- Target-Driven Design: Develop specialist skills in molecular design and ligand-target interactions. You will learn to isolate natural products and conduct rigorous Structure-Activity Relationship (SAR) evaluations to drive discovery.
- Professional Leadership: Transition from student to independent scientist. You will build the confidence to lead original research, navigate multidisciplinary partnerships, and successfully bid for competitive research funding.
Candidates conduct their research in established research groups within the department. Given the global nature of modern science, we emphasise a good knowledge of academic English to ensure our researchers excel in international publications and at global conferences. To guarantee an international profile, the degree includes a mandatory three-month research placement abroad (see section International collaboration) and publishing of at least two first-author publications in high-impact journals during the 4-year PhD cycle.
Entry Criteria:
Candidates are selected based on their performance in a competitive entrance exam, covering basic aspects of organic chemistry and drug design, followed by an academic interview.
Graduate Profile
Graduates posses advanced theoretical and practical knowledge of bioorganic and medicinal chemistry. This training prepares them for leadership roles within both public and private sectors. They have the necessary analytical and organisational skills to lead research teams and manage complex scientific projects.
Career Prospects & Employability
Graduates meet all criteria for finding a job within the chemical and pharmaceutical industries. They are particularly well-suited for roles in:
- Process Chemistry: Developing and optimising synthetic procedures.
- Drug Discovery: Research and development of pharmaceutical substances and therapeutics.
- Natural Products: Isolation and structural characterisation of bioactive compounds.
- Diagnostics: Development of novel diagnostic tools and bioanalytical methods.
Typical Roles: Senior Research Scientist (R&D), Lead Chemist in Organic Synthesis, Bioanalytical Specialist, or Academic Researcher.
