Department of Organic Chemistry » Protective groups in organic synthesis (OCH/PGPG)

Protective groups in organic synthesis (OCH/PGPG)

Course Guarantor

Jakub Stýskala

Form of course completion:

Exam

Annotation:

The aim of this subject is focused to synthesis of more complex organic compounds with using protective groups. Attention is devoted to synthesis when chemical reaction is to be carried out selectively at one reactive site in a multifunctional compound. Students will learn how and which type of reagents to use for synthesis.

Content:

  • Role of protective groups in organic synthesis, requirements to protection and deprotection reactions, strategy of use protective group.
  • Historical development of protective groups, development of new protective groups to nowadays
  • Protection for hydroxyl groups, including 1,2 and 1,3-diols
  • Protection for Phenols and Catechols
  • Protection for Carbonyl group
  • Protection for Carboxyl group
  • Protection for Thiol group
  • Protection for Amino group
  • Protection for Alkyne -CH
  • Protection for Phosphate group
  • Practicing to specific examples

Literature:

  • Theodora W. Greene, Peter G. M. Wuts. Protective Groups in Organic Syntheses. John Wiley and Sons, inc, 1999.
  • A. J. Pearson, W. R. Roush. Handbook of Reagents for Organic Synthesis – Activating Agents and Protecting Groups. John Wiley and Sons, inc, 2000.