Course Guarantor
Pavel Hradil
Form of course completion:
Exam
Annotation:
Knowledge acquired in the master study about the synthesis and reactivity of key heterocyclic compounds both aromatic and non-aromatic character will be broaden. In practical cases, the biological activity of various heterocyclic molecules will be shown.
The most important group of drugs will be discussed:
- CNS drugs (antipsychotics, antidepressants, analgesics, hypnotics, anti-allergics and other substances of this group)
- Agents acting on the autonomic nervous system
- Agents acting on the cholinergic system
- Agents acting on the circulatory system and blood
- Drugs acting on the urinary and digestive system
- Anti-infective agents
- Antitumor chemotherapeutics
Besides the mentioned drug as well as other biologically active substances both natural and synthetic will be discussed.
Literature:
- Patrick G. L. An Introduction to Medicinal Chemistry. Oxford, 2005.
- Hampl F., Rádl S., Paleček J. Farmakochemie. VŠCHT Praha, 2007.
- Lüllmann H, Mohr K., Wehling M. Farmakologie a toxikologie. Grada Praha, 2002.
- Katritzky A. R., Pozharskii A. F. Handbook Heterocyclic Chemistry. Pergamon, Amsterdam, 2000. ISBN 9780080429892.
- Smith H. J. Introduction to the principles of drug design and action. London, 2005.
- Eicher T., Hauptmann S. The Chemistry of Heterocycles. New York, Wiley – VCH, 2003. ISBN 3-527-30720-6.
